"About 78 per cent were men from the service industry and factory workers, who commuted using motorcycles.
"About 55 per cent of the accidents occurred within 5km of the workplace," Dr Subramaniam said after launching the National Safe Commuting to Work 2012 campaign at Universiti Tenaga Nasional yesterday.
He said besides the nation losing young workers, the government also had to fork out compensation to families of the victims.
In 2010, Socso contributed RM630 million, and last year, RM660 million.
During the campaign, themed Partnership in Road Accidents Prevention for Employees at Risk (Proper), which will be on for a month until May 24, video footage of accident-prone areas in Kuala Lumpur, Petaling Jaya, Penang, Johor Baru and Ipoh will be distributed.
The videos will feature comedian Mohd Saifulazam Mohamed Yusoff, 42, better known as Saiful Apek.
Other activities will include techniques on safe motorcycle riding and defensive driving, and safety and awareness programmes.
Dr Subramaniam said his ministry would work with the Department of Safety and Health, National Institute of Occupational Safety and Health and the Malaysian Institute of Road Safety Research during the campaign.